4th International Conference on Pediatrics and Neonatology
Berlin, Germany
Ramy Mohamed
Aja University, Iran
Title: Carotid intima-media thickness, lipid profile, serumamyloidAandvitamin D status in children with familial Mediterranean fever
Biography
Biography: Ramy Mohamed
Abstract
Aim of the work: It was to estimate the carotid intima-media thickness (CIMT), lipid profifile, serum amyloid A and vitamin D in Familial MediterraneanFever(FMF) patients and to explore the relationship between CIMT and FMF. Patients and methods: The study comprised forty-fifive FMF patients diagnosedduring the attack free period and 40 healthy children with similar demographicfeatures as control. The diagnosis of the FMF cases was confirmed byclinical, laboratory assessments and confirmed by the molecular diagnosis.
The CIMT, lipid profile, complete blood picture, serum amyloid A(SAA) levels, vitamin D and the growth pattern were investigated. Results: The study showed no significant difference of CIMT among patientsandcontrols, significant decrease of vitamin D levels, while lipid profile parameters, triglyceride (TG)toHDL-Cholesterol (HDLC) ratio, serum amyloid A were significantly increased. Asignificant correlation was present between the CIMT with the serumcholesterol, low density lipoprotein and triglycerides as well as between SAAand thenumberof attacks. In addition, vitamin D levels showed significant negative correlationwith colchicine. M694I mutation was the most prevalent among FMFpatients. Growth parameters were normal in FMF cases. Conclusion: This study sheds light that the normal CIMT in the FMFpatientsmakes it difficult to describe the children as having subclinical atherosclerosisalthough the higher TG/HDL ratio reflects their risk of atherosclerosis. Moreover, significant decrease of vitamin D in FMF patients was observed. Thegrowthparameters of the FMF patients on regular treatment of colchicine werenotaffected.